The National Cancer Institute (USA)and the National Human Genome Research Institute (USA) launched The Cancer Genome Atlas program to create a comprehensive atlas of the genomic changes involved in more than 20 common types of cancer. This large-scale, high-throughput effort is being carried out by a network of more than 100 researchers at many organizations across the Unitred States. The overarching goal of TCGA is to further scientific understanding of the genomic changes in cancer, thereby improving the ability to diagnose, treat and prevent this devastating disease. All data generated by the TCGA research network are made rapidly available to the research community through the TCGA Data Portal.
Monday, May 28, 2012
Sunday, May 27, 2012
Reduce your weight and have vigorous physical activity to reduce Breast cancer risk
VIGORUS PHYSICAL ACTIVITY REDUCES BREAST CANCER RISK IN POSTMENOPAUSAL WOMEN
In a large scale study using 32,269 women Scientists from National Cancer Institute (USA) found an inverse association between physical activity and postmenopausal breast cancer i.e women with more vigorus physical activity have a reduced risk for breast cancer. But this reduction was not there in overweight women and is there only lean women (normal weight). There is no relation between the reduced risk and by hormone receptor status. Physical activity is suggested to act through underlying biological mechanisms that are independent of body weight control.
GOOD NEWS: DECLINE IN DEATH DUE TO MOST COMMON CANCERS IN USA
Declining Cnacer Deaths:
Overall cancer death rates have
been declining among children since the 1970s and among adults since the 1990s.
Death rates from all cancers combined decreased from 1999 to 2008, continuing a
decline that began in the early 1990s, among men and among women in most racial
and ethnic groups. Death rates decreased from 1999 to 2008 for most cancer
sites, including the 4 most common cancers (lung, colorectum, breast, and
prostate). The incidence of prostate and colorectal cancers also decreased from
1999 to 2008. Lung cancer incidence declined from 1999 to 2008 among men and
from 2004 to 2008 among women. Breast cancer incidence decreased from 1999 to
2004 but was stable from 2004 to 2008. Trends
in death rates for the most recent 10-year period (1999-2008) show an average
1.7% decrease per year among men and an average 1.3% decrease per year among
women as well as among children ages 0 to 19 years. Death rates decreased 1.5%
per year among children ages 0 to 14 years. Death rates for 11 of the 17 most
common cancers among men and for 14 of the 18 most common cancers among women
(lung, colon and rectum, kidney, brain, stomach, oral cavity, leukemia,
non-Hodgkin lymphoma, and myeloma among both men and women; prostate and larynx
among men; and breast, ovary, urinary bladder, esophagus, and gallbladder among
women) decreased during the most recent 10-year (1999-2008) and 5-year
(2004-2008) periods.
Saturday, May 26, 2012
A compound present in broccoli/broccoli sprouts can treat breast cancer
BREAKTHROUGH DISCOVERY
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
In the previous post I have mentioned about the Breast cancer stem cells which are more tumorigenic than normal differentiated breast cancer cells. These stem cells are dangerous and controlling them is very important for cancer prevention. In a breakthrough discovery, Scientists from University of Michigan have identified compounds that can inhibit the breast cancer stem cells. Sulforaphane a compound found in broccoli/broccoli sprouts Sulforaphane inhibits breast CSCs and downregulates the Wnt/beta-catenin self-renewal pathway. These findings support the use of sulforaphane for the chemoprevention of breast cancer stem cells. Further clinical studies can result in a new drug for breast cancer.
[Click Here to Read the Original Article]
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